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Ritonavir or lopinavir/ritonavir tremendously maximize plasma concentrations of oxycodone in nutritious human volunteers as a consequence of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin enormously reduces plasma concentrations of oxycodone because of sturdy induction of CYP3A4.An extensive affected person historical past must be taken to doc con

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